Recommended criteria for the evaluation of bacterial mutagenicity data (Ames test)
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چکیده
منابع مشابه
Mutagenicity of flavonoids assayed by bacterial reverse mutation (Ames) test.
The mutagenicity of ten flavonoids was assayed by the Ames test, in Salmonella typhimurium strains TA98, TA100 and TA102, with the aim of establishing hydroxylation pattern-mutagenicity relationship profiles. The compounds assessed were: quercetin, kaempferol, luteolin, fisetin, chrysin, galangin, flavone, 3-hydroxyflavone, 5-hydroxyflavone and 7-hydroxyflavone. In the Ames assay, quer...
متن کاملActivity of quinolones in the Ames Salmonella TA102 mutagenicity test and other bacterial genotoxicity assays.
Eight quinolones were examined for their bacterial mutagenicity in the Ames Salmonella TA102 assay and for their effects in other bacterial genotoxicity assays. In the quantitative Ames plate incorporation assay, all eight quinolones induced His+ deletion reversion in Salmonella tester strain TA102, with maximum reversion observed at about two to eight times the MIC. The quinolones also induced...
متن کاملEvolutionary Ensemble for In Silico Prediction of Ames Test Mutagenicity
Driven by new regulations and animal welfare, the need to develop in silico models has increased recently as alternative approaches to safety assessment of chemicals without animal testing. This paper describes a novel machine learning ensemble approach to building an in silico model for the prediction of the Ames test mutagenicity, one of a battery of the most commonly used experimental in vit...
متن کاملMutagenicity of glutathione and cysteine in the Ames test.
Postmitochondrial supernatant from rat liver and kidney homogenates transformed cysteine into a mutagen that reverted bacteria of the strain Salmonella typhimurium TA100 to histidine independence. Glutathione was also activated by kidney postmitochondrial supernatant but not by liver preparations. Hence, important endogenous compounds of mammals are positive in the most commonly used short-term...
متن کاملNonparametric regression analysis of data from the Ames mutagenicity assay.
The Ames assay has received widespread attention from statisticians because of its popularity and importance to risk assessment. However, investigators have yet to routinely apply modern regression methods that have been available for more than a decade. We study yet another approach, the application of nonparametric regression techniques, not as the ultimate solution but rather as a framework ...
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ژورنال
عنوان ژورنال: Mutation Research/Genetic Toxicology and Environmental Mutagenesis
سال: 2019
ISSN: 1383-5718
DOI: 10.1016/j.mrgentox.2019.07.004